Study wrapper · #1001
Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial.
Mawu FO, Anwar AI, Djawad K, et al. Acta dermatovenerologica Alpina, Pannonica, et Adriatica. 2025.
DOI: 10.15570/actaapa.2025.acne-gshPubMed: 41014073
Editor's note
A randomized, placebo-controlled trial (40 subjects) with oral glutathione as the direct intervention in acne. Reductions in nitric oxide and IL-1α did not reach statistical significance and clinical improvement was modest, so it is best read as a small negative-to-inconclusive trial. Human evidence directly on glutathione, warranting cautious coverage.
Plain-language abstract
In a small randomized trial, oral glutathione showed a non-significant trend toward lower inflammatory markers and modest clinical improvement in mild-to-moderate acne.
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