Study wrapper · #973
Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors.
Gu YM, Yuan QN, Li X, et al. Acta pharmacologica Sinica. 2026.
DOI: 10.1038/s41401-025-01635-2PubMed: 40847076
Editor's note
A cryo-EM structural study resolving how cagrilintide engages both amylin and calcitonin receptors via a shared binding mode. It clarifies the molecular basis of the drug's dual-receptor activity. Mechanistic rather than clinical, but directly focused on a tracked peptide.
Plain-language abstract
This structural biology study used cryo-EM to show how cagrilintide binds and activates amylin and calcitonin receptors.
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