Weight regain now has a timetable — and a Nature mouse study tests the limits of semaglutide enthusiasm
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Study wrapper · #1350

The Evolution of Medications for Obesity Management.

Gill J, Sumithran P JGH open : an open access journal of gastroenterology and hepatology. 2026.

Editor's note

A narrative review rather than a systematic one, so study selection reflects the authors' judgment and no pooled estimates are offered. Its value is as a readable synthesis of how the field moved past a history of market withdrawals to the current incretin class, with headline efficacy figures that align with the pivotal trials. Useful orientation; no new data.

Plain-language abstract

This narrative review traces how obesity medications have evolved, noting that today's injectable incretin drugs, semaglutide and tirzepatide, produce average weight loss of 15-20% over roughly 12-18 months along with cardiovascular, kidney, and metabolic benefits.