Study wrapper · #1107
Resolution of anhedonia-like symptoms in patients treated for obesity with tirzepatide: A three-case series.
Nadolsky S, Kessel S, Krumm ZA, et al. Obesity pillars. 2026.
DOI: 10.1016/j.obpill.2026.100302PubMed: 42518361
Editor's note
A three-case series flagging a possible neurobehavioral effect of high-dose tirzepatide, with symptom improvement reported after dose reduction. As an uncontrolled case series it raises a monitoring consideration rather than establishing incidence or causation.
Plain-language abstract
This three-patient case series describes anhedonia-like symptoms, such as reduced motivation and emotional flatness, in women on high-dose tirzepatide, with improvement after dose reduction. The small, uncontrolled design means the link remains tentative.
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