Study wrapper · #1060
A Case of Severe Hypercalcemia in a Patient Taking Tirzepatide: Potential Risk Factors.
Editor's note
A single-patient case report raising a possible association between tirzepatide and severe hypercalcemia in the setting of multiple contributing factors, including a thiazide, calcium and vitamin D supplements, and kidney disease. A case report cannot establish causation, and the concurrent medications and comorbidities complicate attribution. Readers can read this as a signal for calcium monitoring in similar high-risk scenarios rather than evidence of a general tirzepatide effect.
Plain-language abstract
This single case report describes a 75-year-old woman with chronic kidney disease and prior parathyroid surgery who developed severe high blood calcium about a month after starting tirzepatide while also taking a thiazide diuretic, a calcium supplement, and vitamin D. Her calcium normalized after fluids and stopping the implicated medications.