Study wrapper · #993
Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model.
Vahle B, Weidner S, Tomalka A, et al. Circulation. Heart failure. 2026.
DOI: 10.1161/circheartfailure.126.014397PubMed: 42290373
Editor's note
A controlled rat study showing SS-31 improving skeletal-muscle function in a HFpEF model, with a plausible cardiolipin-stabilization mechanism. Evidence remains preclinical and animal-only.
Plain-language abstract
In a rat model of heart failure with preserved ejection fraction, elamipretide (SS-31) improved skeletal-muscle force and reduced muscle atrophy, apparently by stabilizing cardiolipin.
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