Study wrapper · #985
Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis.
Dong W, Zhang W, Huang L, et al. Journal of advanced research. 2026.
DOI: 10.1016/j.jare.2026.03.014PubMed: 41831680
Editor's note
An animal and cell study in which SS-31 is a central intervention for preserving cardiolipin after ischemia-reperfusion. Evidence is preclinical and mechanistic. A solid data point for SS-31 in stroke research.
Plain-language abstract
In mouse and cell stroke models, the cardiolipin-targeting peptide SS-31 preserved cardiolipin and was associated with reduced ischemia-reperfusion brain injury.
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