Study wrapper · #984
Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury.
Song Z, Ban Z, Zhao H, et al. Neurochemistry international. 2026.
DOI: 10.1016/j.neuint.2026.106171PubMed: 42082001
Editor's note
An animal study in mice with supporting cell-culture work; SS-31 is the primary intervention. Results are associative and preclinical, not evidence of benefit in humans. A reasonable data point for tracking SS-31 in neural-injury research.
Plain-language abstract
In a mouse model of spinal cord injury, SS-31 was associated with improved locomotor recovery, less tissue damage, and better mitochondrial measures.
Related coverage
Supported
Oral Colon- and Mitochondria-Targeted Nanoparticles Alleviate Ulcerative Colitis by Reeducating Macrophage Polarization via SIRT3/FOXO3a-Mediated Mitochondrial Restoration.
Journal of gastroenterology and hepatologyn=——2026
Mixed
Seawater immersion reshapes the temporal dynamics of traumatic brain injury and reveals mitochondrial oxidative stress as a modifiable therapeutic target.
Experimental neurologyn=——2026
Supported
Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.
Brain, behavior, and immunityn=——2026