Study wrapper · #950
Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?
Yassin Alsabbagh A, Bhujel N, Singh RP International journal of oral and maxillofacial surgery. 2025.
DOI: 10.1016/j.ijom.2025.03.014PubMed: 40210573
Editor's note
This single case report raises a possible association between Melanotan II nasal spray use and oral mucosal malignant melanoma in a young woman. As an isolated case it cannot establish causation, and the authors frame it as a question warranting awareness rather than a proven link. It is directly about the peptide and adds to documented safety concerns around unregulated use.
Plain-language abstract
A case report describes a 22-year-old woman who developed an oral mucosal malignant melanoma after using a Melanotan II nasal spray for tanning.
Related coverage
Weak / none
Five primary melanomas in situ in a patient with recent tanning bed use, melanotan exposure, and anabolic hormone use.
JAAD case reportsn=——2026
Weak / none
Unregulated Melanotan Use Promoted via Social Media: Emerging Dermatologic and Public Health Risks.
International journal of dermatologyn=——2026
Weak / none
Depigmented Facial and Neck Patches Following Melanotan Use in a Patient With Atopic Dermatitis and Alopecia Areata.
Clinical and experimental dermatologyn=——2026