Study wrapper · #896
Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review.
Au HCT, Zheng YJ, Le GH, et al. Obesity reviews. 2026.
DOI: 10.1111/obr.70120PubMed: 41792979
Editor's note
This systematic review of adverse-event reports found semaglutide and liraglutide associated with elevated reported odds of suicidal ideation, with tirzepatide showing a nonsignificant trend. Both tracked peptides are genuine subjects and the safety topic is important. Critically, the data are disproportionality signals from spontaneous reports and the authors state no causality is apparent, so this is a hypothesis, not a confirmed risk.
Plain-language abstract
A systematic review of pharmacovigilance reports found semaglutide and liraglutide associated with higher reported odds of suicidal ideation, though the authors found no evidence of a causal link.
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