Study wrapper · #856
Revision Medialization Thyroplasty for Glottic Insufficiency Amid Rapid Weight Loss on Semaglutide.
Xu K, Weitzman R, Yu M, et al. The Laryngoscope. 2026.
DOI: 10.1002/lary.70732PubMed: 42439301
Editor's note
A single case report linking rapid semaglutide-associated weight loss to vocal fold atrophy and glottic insufficiency, resolved with revision thyroplasty. It adds an unusual soft-tissue observation to the growing catalog of downstream effects of fast weight loss, but with one patient and an obvious confounder (prior thyroplasty nine years earlier) the causal thread is loose. A minor safety curiosity rather than a substantive finding.
Plain-language abstract
In one older patient, rapid weight loss on semaglutide coincided with vocal-cord thinning and voice deterioration that required corrective surgery.
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