Study wrapper · #855
Severe Perioperative Lactic Acidosis and Hyperglycemia Responsive to Thiamine in a Patient With Prior Semaglutide Use and Restrictive Dieting: A Case Report.
Kataria S, Pylypiv O, Fahrenkrog M A&A practice. 2026.
DOI: 10.1213/xaa.0000000000002253PubMed: 42439433
Editor's note
A single case report flagging that GLP-1-driven appetite reduction plus restrictive dieting may unmask thiamine deficiency, which surfaced here as severe perioperative lactic acidosis that reversed rapidly with intravenous thiamine. Semaglutide is one contributing factor among several rather than the study's focus, and causality in a single patient is speculative. The safety signal is worth logging for readers on GLP-1 agonists with limited nutritional intake, but the evidence weight is minimal.
Plain-language abstract
In one patient, prior semaglutide use combined with restrictive dieting may have contributed to a dangerous perioperative thiamine deficiency that resolved quickly once vitamin B1 was given.
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