Study wrapper · #1394
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
Banerjee AA, Bhanarkar SR, Kashikar S, et al. Clinica chimica acta; international journal of clinical chemistry. 2027.
DOI: 10.1016/j.cca.2026.121207PubMed: 42364891
Editor's note
A prospective, well-structured diagnostic study (n=96) with ROC and decision-curve analysis addressing a genuine clinical bottleneck. Note this concerns endogenous kisspeptin-10 measured as a biomarker, not administered peptide — it speaks to kisspeptin biology, not to any use protocol. Single-population Indian cohort with moderate sensitivity (72.7%); the cut-off needs external validation before clinical adoption.
Plain-language abstract
In girls being evaluated for early puberty, the ratio of blood kisspeptin-10 to basal LH distinguished true central precocious puberty from benign premature breast development with about 78% accuracy — potentially reducing the need for GnRH stimulation testing.
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