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Study wrapper · #1359

Implications of Glucagon-Like Peptide-1 Receptor Agonists in Otolaryngology - Head and Neck Surgery: A Review.

Anderson BJ, Van Daele DJ, Claussen AD, et al. The Annals of otology, rhinology, and laryngology. 2026.

Editor's note

A specialty-focused narrative review that usefully collects effects scattered across the head and neck literature, both favorable and concerning. The evidence quality behind each claim varies widely — the sleep apnea benefit rests on randomized trial data, while the sinusitis, olfaction, and hearing threads are early and speculative. The balanced handling of the thyroid cancer question, where animal signals have not been confirmed in population studies, is appropriately cautious.

Plain-language abstract

This review maps how GLP-1 drugs intersect with ear, nose, and throat care — from reflux, chronic cough, and aspiration risk around surgery to benefits in obstructive sleep apnea, possible effects on smell and sinus disease, and open questions about hearing and thyroid safety.