Weight regain now has a timetable — and a Nature mouse study tests the limits of semaglutide enthusiasm
Read the Sunday Brief →

Study wrapper · #1142

The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.

Roskoski R Pharmacological research. 2026.

Editor's note

A tidy reference review of incretin pharmacology from a veteran of the drug-mechanism literature. The most useful sections for our readers explain the molecular engineering behind long-acting peptides — fatty acid acylation piggybacking on albumin — and lay out the current approval map, with retatrutide still in trials. Nothing new here, but a well-organized primer on how this drug class actually works.

Plain-language abstract

A pharmacology review walks through how GLP-1 and GIP receptor agonist drugs work — from semaglutide and tirzepatide to the investigational triple agonist retatrutide — including the fatty-acid engineering that lets these peptides last a week in the body instead of minutes.