Study wrapper · #1142
The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.
Roskoski R Pharmacological research. 2026.
DOI: 10.1016/j.phrs.2026.108365PubMed: 42556625
Editor's note
A tidy reference review of incretin pharmacology from a veteran of the drug-mechanism literature. The most useful sections for our readers explain the molecular engineering behind long-acting peptides — fatty acid acylation piggybacking on albumin — and lay out the current approval map, with retatrutide still in trials. Nothing new here, but a well-organized primer on how this drug class actually works.
Plain-language abstract
A pharmacology review walks through how GLP-1 and GIP receptor agonist drugs work — from semaglutide and tirzepatide to the investigational triple agonist retatrutide — including the fatty-acid engineering that lets these peptides last a week in the body instead of minutes.
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