Impact of semaglutide introduction on the use of triptans: an interrupted-time series.

An inventive use of pharmacy records to probe the emerging semaglutide-migraine question without a trial. The nationwide scale is a strength, and the pattern — reductions concentrated in existing triptan users, women, and younger adults — is internally coherent. But triptan refills are a proxy, not a headache diary, and weight loss itself could account for some of the change. A modest, suggestive signal that strengthens the case for a proper randomized study.