Prescription Sequence Symmetry Analysis of Glucagon-Like Peptide-1 Receptor Agonists and Neuropsychiatric Conditions.

This prescription-sequence analysis reports semaglutide as the dominant agent and finds inverse associations with later antidepressant and substance-use medication starts. The design detects temporal patterns but cannot establish causation or rule out confounding by indication. Regard the inverse associations as signals warranting dedicated study rather than evidence of a therapeutic effect.